These ingredients have been used safely in many cosmetic, pharmaceutical and food applications for about a century. Because of this wide spread use, most people have been exposed orally and/or topically on both an acute and chronic basis. The lack of any symptoms being linked to this long period of use is a testimony to the safety of these products in their wide range of applications. The cosmetic industry has also encouraged a careful review of available studies on these ingredients by a board of independent scientists. After considering all of these data, the US Food and Drug Administration and other cosmetic regulatory agencies around the world have allowed for unrestricted cosmetic use.