Yes, although the technology of the ARTISTRY Skin Enhancer was only matched to the natural resonance of each Signature Select Personalized Serum. When using ARTISTRY Skin Enhancer with other ARTISTRY serums, use the mode to match the serum. E.g. Intensives Skincare 14 Night Restore Program could be used with the Radiance or the Wrinkle mode. The Intensive Skincare Advanced Skin Refinisher can be used with the Lift mode. The ARTISTRY Men Serum Concentrate can be used with the Wrinkle mode.