If you are looking for the very best in anti-ageing skincare, the Supreme LX Regenerating Cream is our most luxurious and technologically advanced anti-ageing face cream. The combination of the CellEffect 24 Complex, Cardiolopin and Gardenia Grandiflora Stem Cells help to recharge the skin’s cellular energy. You can use the Supreme LX Regenerating Cream day and night. I would suggest you apply over the Anti-Wrinkle Firming Serum at night and the ARTISTRY Signature Select Personalized Serum during the day. If your skin is combination, I would suggest a lighter moisturiser for day wear.